Cissus is an ancient herbal remedy used for over 2,000 years in Africa and in Ayurvedic Indian medicine. Its traditional nickname is "bone-knitter" and we believe that it's aptly named! Scientific research of cissus extract indicates it positively promotes healthy bone turnover and bone strength maintenance. In clinical research with humans, it revealed its gift in promoting healthy bone mineral composition and providing powerful antioxidant support to help protect bone function. Our cissus is hand-gathered and sustainably wild-harvested just for Synergy. It is SuperPure®, meaning it has been extracted with only the purest processes. We've included the full amount of cissus extract proven to be safe and effective in scientific studies.