Folate (L-5-MTHF)

L-5-methyltetrahydrofolate (L-5-MTHF), sometimes referred to as L-methylfolate, is the body’s bioactive form of folate and the one most commonly found in food. In general, folate is a B vitamin (vitamin B9) that occurs naturally in foods and can also be taken in supplement form. Unlike other forms of man-made folic acid, L-5-MTHF is already in its metabolically active form, which means it can be easily assimilated and readily used by our bodies. This especially benefits those that have common genetic mutations in methylation enzymes. Active folate provides essential support for blood cell formation and cellular repair, maintaining healthy circulation and immune function, and fueling the brain. Folate is best known for its ability to support proper fetal neural tube development in early pregnancy when taken in optimal amounts.


Our L-5-MTHF is an exceptionally pure second-generation folate made without the use of toxic solvents. It is a patented C-crystalline calcium salt, with high purity, stability, and excellent bioavailability.

A Year ago